ACNE
ACNE VULGARIS
It is a self limited disorder
It is seen mainly in teenagers and young adults
PATHOLOGY
Mainly by increase in sebum production by sebaceous glands after puberty.
small cysts called comedons,form in hair follicles due to blockage of follicular orifice
by retention of sebam and keratinous material.
Proprionobacterium acnes bacteria with in comedones release free fatty acids from sebum, causes inflammation within the cysts, and results in rupture of the cyst wall.
Clinical features
the clinical hallmark of acne vulgaris is the comedone,2types
1)closed (whitehead)
2)open(blackhead)
Closedcomedones-
they appear as 1 to 2mm pebbly white papules
they are the precursors of inflammatory lesions of acne vulgaris
open comedones
these have a large dilated follicular orifice
and filled with easily expressible oxidized,darkened,oily debries
comedones are usually accompanied by inflammatory lesions
1)papule
2)pustules
3)nodules
sites mainly seen
the earlist lesions seen on the forehead subsequently more typical inflammatory
lesions on the cheek,nose and chine.
most common locations for acne is face ,uncommons sites are chest and back.
factors influence acne
1)glucocorticoids,applied topically or adminstered systemically in high doses may
elicit acne
2)systemic medications such as lithium,isoniazid,halogens,phenytoin
It is a self limited disorder
It is seen mainly in teenagers and young adults
PATHOLOGY
Mainly by increase in sebum production by sebaceous glands after puberty.
small cysts called comedons,form in hair follicles due to blockage of follicular orifice
by retention of sebam and keratinous material.
Proprionobacterium acnes bacteria with in comedones release free fatty acids from sebum, causes inflammation within the cysts, and results in rupture of the cyst wall.
Clinical features
the clinical hallmark of acne vulgaris is the comedone,2types
1)closed (whitehead)
2)open(blackhead)
Closedcomedones-
they appear as 1 to 2mm pebbly white papules
they are the precursors of inflammatory lesions of acne vulgaris
open comedones
these have a large dilated follicular orifice
and filled with easily expressible oxidized,darkened,oily debries
comedones are usually accompanied by inflammatory lesions
1)papule
2)pustules
3)nodules
sites mainly seen
the earlist lesions seen on the forehead subsequently more typical inflammatory
lesions on the cheek,nose and chine.
most common locations for acne is face ,uncommons sites are chest and back.
factors influence acne
1)glucocorticoids,applied topically or adminstered systemically in high doses may
elicit acne
2)systemic medications such as lithium,isoniazid,halogens,phenytoin
and phenobarbital may produce or aggravate preexisting acne.
3)application of comedogenic topical agents
treatment
it may be treated with either localor systemic medications
Areas affected with acne should be kept clean.
topical agents-
prevent formation of comedones
1)retinoic acid
2)benzoyl peroxide
3)salicylic acids
topical antibacterial agents
3)application of comedogenic topical agents
treatment
it may be treated with either localor systemic medications
Areas affected with acne should be kept clean.
topical agents-
prevent formation of comedones
1)retinoic acid
2)benzoyl peroxide
3)salicylic acids
topical antibacterial agents
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